先端医療研究センター・感染症分野先端医療研究センター・感染症分野

研究成果 (抜粋)

〜2014

  • Switching and emergence of CTL epitopes in HIV-1 infection.
    Han C, Kawana-Tachikawa A, Shimizu A, Zhu D, Nakamura H, Adachi E, Kikuchi T, Koga M, Koibuchi T, Gao GF, Sato Y, Yamagata A, Martin E, Fukai S, Brumme ZL, Iwamoto A.
    Retrovirology. 2014 May;11(1):38.

〜2013

  • Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection.
    Shimizu, A., Kawana-Tachikawa, A., Yamagata, A., Han, C., Zhu, D., Sato, Y., Nakamura, H., Koibuchi, T., Carlson, J., Martin, E., Brumme, C.J., Shi, Y., Gao, G.F., Brumme, Z.L., Fukai, S., Iwamoto, A.
    Sci. Rep. 2013 Nov; 3: 3097.
  • Development of a Rapid Cell-Fusion-based Phenotypic HIV-1 Tropism Assay.
    Teeranaipong, P., Hosoya, N., Kawana-Tachikawa, A., Fujii, T., Koibuchi, T., Nakamura, H., Koga, M., Kondo, N., Gao, G.F., Hoshino, H., Matsuda, Z., Aikichi Iwamoto.
    Journal of the International AIDS Sciety 2013 Sep;16 (1):18723.
  • Significant reductions in Gag-protease-mediated HIV-1 replication capacity during the course of the epidemic in Japan.
    Nomura S, Hosoya N, Brumme ZL, Brockman MA, Kikuchi T, Koga M, Nakamura H, Koibuchi T, Fujii T, Carlson JM, Heckerman D, Kawana-Tachikawa A, Iwamoto A, Miura T.
    J Virol. 2013 Feb;87(3):1465-76.
  • Tuberculosis examination using whole blood interferon-gamma release assay among health care workers in a Japanese hospital without tuberculosis-specific wards.
    Adachi E, Kogayu M, Fujii T, Mae H, Shimizu S, Iwai Y, Shibata H, Suzuki M, Imai K, and Koibuchi T.
    Springerplus. 2013;2:440.
  • Hemophagocytic syndrome in an acute human immunodeficiency virus infection.
    Adachi E, Koibuchi T, Imai K, Kikuchi T, Shimizu S, Koga M, Nakamura H, Iwamoto A, Fujii T. 
    Intern Med. 2013;52(5):629-32.

〜2012

  • Improved neutralizing antibody response in the second season after a single dose of pandemic (H1N1) 2009 influenza vaccine in HIV-1-positive adults.
    Kikuchi T, Iwatsuki-Horimoto K, Adachi E, Koga M, Nakamura H, Hosoya N, Kawana-Tachikawa A, Koibuchi T, Miura T, Fujii T, Kawaoka Y, Iwamoto A. Vaccine. 2012 Jun 6;30(26):3819-23.
  • Favourable outcome of progressive multifocal leukoencephalopathy with mefloquine treatment in combination with antiretroviral therapy in an HIV-infected patient.
    Adachi E, Koibuchi T, Imai K, Kikuchi T, Koga M, Nakamura H, Miura T, Iwamoto A, Fujii T. Int J STD AIDS. 2012 Aug;23(8):603-5
  • Liver dysfunction in patients with early syphilis: a retrospective study.
    Adachi E, Koibuchi T, Okame M, Sato H, Kikuchi T, Koga M, Nakamura H, Iwamoto A, Fujii T. J Infect Chemother. 2012 Jun 13.
  • Shigella sonnei outbreak among men who have sex with men in Tokyo.
    Okame M, Adachi E, Sato H, Shimizu S, Kikuchi T, Miyazaki N, Koga M, Nakamura H, Suzuki M, Oyaizu N, Fujii T, Iwamoto A, Koibuchi T. Jpn J Infect Dis. 2012;65(3):277-8.

〜2011

  • Imbalanced Production of Cytokines by T Cells Associates with the Activation/Exhaustion Status of Memory T Cells in Chronic HIV Type 1 Infection.
    Nakayama K, Nakamura H, Koga M, Koibuchi T, Fujii T, Miura T, Iwamoto A, Kawana-Tachikawa A.
    AIDS Res Hum Retroviruses. 2011 Sep 23. [Epub ahead of print]
  • Case of secondary syphilis presenting with unusual complications: syphilitic proctitis, gastritis, and hepatitis.
    Adachi E, Koibuchi T, Okame M, Sato H, Imai K, Shimizu S, Tsurita G, Oyaizu N, Iwamoto A, Fujii T.
    J Clin Microbiol. 2011 Dec;49(12):4394-6.
  • Cerebral schistosomiasis due to Schistosoma haematobium confirmed by PCR analysis of brain specimen.
    Imai K, Koibuchi T, Kumagai T, Maeda T, Osada Y, Ohta N, Koga M, Nakamura H, Miura T, Iwamoto A, Fujii T.
    J Clin Microbiol. 2011 Oct;49(10):3703-6.
  • Kinetics of serum β-D-glucan after Pneumocystis pneumonia treatment in patients with AIDS.
    Koga M, Koibuchi T, Kikuchi T, Nakamura H, Miura T, Iwamoto A, Fujii T.
    Intern Med. 2011;50(13):1397-401.
  • Pulmonary nocardiosis caused by Nocardia exalbida complicating Pneumocystis pneumonia in an HIV-infected patient.
    Imai K, Koibuchi T, Kikuchi T, Koga M, Nakamura H, Miura T, Gonoi T, Yazawa K, Iwamoto A, Fujii T.
    J Infect Chemother. 2011 Aug;17(4):547-51.

〜2010

  • Long-term successful control of super-multidrug-resistant human immunodeficiency virus type 1 infection by a novel combination therapy of raltegravir, etravirine, and boosted-darunavir.
    Nakamura H, Miyazaki N, Hosoya N, Koga M, Odawara T, Kikuchi T, Koibuchi T, Kawana-Tachikawa A, Fujii T, Miura T, Iwamoto A.
    J Infect Chemother. 2010 Jun 30. [Epub ahead of print]
  • Changes in impact of HLA class I allele expression on HIV-1 plasma virus loads at a population level over time.
    Koga M, Kawana-Tachikawa A, Heckerman D, Odawara T, Nakamura H, Koibuchi T, Fujii T, Miura T, Iwamoto A.
    Microbiol Immunol. 2010 Apr;54(4):196-205.
  • Influence of polymorphism in dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related (DC-SIGNR) gene on HIV-1 trans-infection.
    Zhu D, Kawana-Tachikawa A, Iwamoto A, Kitamura Y.
    Biochem Biophys Res Commun. 2010 Mar 19;393(4):598-602.

〜2009

  • Generation of recombinant monoclonal antibodies against an immunodominant HLA-A*2402-restricted HIV type 1 CTL epitope.
    Nunoya J, Nakashima T, Kawana-Tachikawa A, Kiyotani K, Ito Y, Sugimura K, Iwamoto A.
    AIDS Res Hum Retroviruses. 2009 Sep;25(9):897-904.
  • Highly restricted T-cell receptor repertoire in the CD8+ T-cell response against an HIV-1 epitope with a stereotypic amino acid substitution.
    Miyazaki E, Kawana-Tachikawa A, Tomizawa M, Nunoya J, Odawara T, Fujii T, Shi Y, Gao GF, Iwamoto A.
    AIDS. 2009 Mar 27;23(6):651-60.

〜2008

  • Comparison between Sendai virus and adenovirus vectors to transduce HIV-1 genes into human dendritic cells.
    Hosoya N, Miura T, Kawana-Tachikawa A, Koibuchi T, Shioda T, Odawara T, Nakamura T, Kitamura Y, Kano M, Kato A, Hasegawa M, Nagai Y, Iwamoto A.
    J Med Virol. 2008 Mar;80(3):373-82.
  • Unusual radiological findings of Fasciola hepatica infection with huge cystic and multilocular lesions.
    Maeda T, Yamada H, Akao N, Iga M, Endo T, Koibuchi T, Nakamura T, Odawara T, Iwamoto A, Fujii T.
    Intern Med. 2008;47(5):449-52.

2004〜2007

  • Pneumocystis pneumonia in patients with HIV infection: clinical manifestations, laboratory findings, and radiological features.
    Fujii T, Nakamura T, Iwamoto A.
    J Infect Chemother. 2007 Feb;13(1):1-7.
  • Antimicrobial therapy for patients with HIV infection
    Koibuchi T, Iwamoto A.
    Nippon Naika Gakkai Zasshi. 2006 Nov 10;95(11):2214-9.
  • Analysis of HIV-1 sequences before and after co-infecting syphilis.
    Koga I, Odawara T, Matsuda M, Sugiura W, Goto M, Nakamura T, Iwamoto A.
    Microbes Infect. 2006 Nov-Dec;8(14-15):2872-9.
  • Peptide-loaded dendritic-cell vaccination followed by treatment interruption for chronic HIV-1 infection: a phase 1 trial.
    Ide F, Nakamura T, Tomizawa M, Kawana-Tachikawa A, Odawara T, Hosoya N, Iwamoto A.
    J Med Virol. 2006 Jun;78(6):711-8.
  • Successful guidance by automatic output of music and verbal messages for daily behavioural disturbances of three individuals with dementia.
    Yasuda K, Beckman B, Yoneda M, Yoneda H, Iwamoto A, Nakamura T.
    Neuropsychol Rehabil. 2006 Feb;16(1):66-82.
  • AIDS-related cerebral toxoplasmosis with hyperintense foci on T1-weighted MR images: a case report.
    Maeda T, Fujii T, Matsumura T, Endo T, Odawara T, Itoh D, Inoue Y, Okubo T, Iwamoto A, Nakamura T.
    J Infect. 2006 Oct;53(4):e167-70.
  • Clinical characteristics of imported malaria in Japan: analysis at a referral hospital.
    Miura T, Kimura M, Koibuchi T, Endo T, Nakamura H, Odawara T, Wataya Y, Nakamura T, Iwamoto A.
    Am J Trop Med Hyg. 2005 Sep;73(3):599-603.
  • Questionnaire-based analysis of mefloquine chemoprophylaxis for malaria in a Japanese population.
    Matsumura T, Fujii T, Miura T, Koibuchi T, Endo T, Nakamura H, Odawara T, Iwamoto A, Nakamura T.
    J Infect Chemother. 2005 Aug;11(4):196-8.
  • Influence of single-nucleotide polymorphisms in the multidrug resistance-1 gene on the cellular export of nelfinavir and its clinical implication for highly active antiretroviral therapy.
    Zhu D, Taguchi-Nakamura H, Goto M, Odawara T, Nakamura T, Yamada H, Kotaki H, Sugiura W, Iwamoto A, Kitamura Y.
    Antivir Ther. 2004 Dec;9(6):929-35.
  • Detection of Toxoplasma gondii by polymerase chain reaction in cerebrospinal fluid from human immunodeficiency virus-1-infected Japanese patients with focal neurological signs.
    Goto M, Takahashi T, Kanda T, Iwamoto A.
    J Int Med Res. 2004 Nov-Dec;32(6):665-70.
  • Frequent transmission of cytotoxic-T-lymphocyte escape mutants of human immunodeficiency virus type 1 in the highly HLA-A24-positive Japanese population.
    Furutsuki T, Hosoya N, Kawana-Tachikawa A, Tomizawa M, Odawara T, Goto M, Kitamura Y, Nakamura T, Kelleher AD, Cooper DA, Iwamoto A.
    J Virol. 2004 Aug;78(16):8437-45.
  • Current concepts in SARS treatment.
    Fujii T, Nakamura T, Iwamoto A.
    J Infect Chemother. 2004 Feb;10(1):1-7. Review.
  • Antibody-dependent cellular cytotoxicity via humoral immune epitope of Nef protein expressed on cell surface.
    Yamada T, Watanabe N, Nakamura T, Iwamoto A.
    J Immunol. 2004 Feb 15;172(4):2401-6.